A review of non-invasive insulin delivery systems for diabetes therapy in clinical trials over the past decade

N Easa, RG Alany, M Carew, A Vangala - Drug discovery today, 2019 - Elsevier
DM into: type 1 (T1DM), type 2 (T2DM), gestational diabetes, … with conventional insulin aspart
(Novorapid ® or NovoLog ® … , and insulin suspended, embedded or dispersed in an oil or …

[HTML][HTML] Fast-acting insulin aspart and the need for new mealtime insulin analogues in adults with type 1 and type 2 diabetes: a Canadian perspective

P Senior, I Hramiak - Canadian Journal of Diabetes, 2019 - Elsevier
… space, to accelerate the flow and dispersion of insulin (50). In … -lowering effect during the
2 h after a liquid meal test (ETD –… aspart in CSII is currently being evaluated in clinical trials, …

Continuous subcutaneous insulin infusion therapy and multiple daily insulin injections in type 1 diabetes mellitus: a comparative overview and future horizons

H Thabit, R Hovorka - Expert Opinion on Drug Delivery, 2016 - Taylor & Francis
… and dispersion of phenol. The diffusion of zinc then causes … strategies are introducing charge
repulsion (in insulin aspart … a large randomised controlled study that evaluated the effects …

Insulin therapy development beyond 100 years

PD Home, R Mehta - The Lancet Diabetes & Endocrinology, 2021 - thelancet.com
… the effective management of type 1 diabetes still needs to be … with biosimilar insulin lispro
to achieve faster dispersion in … AT247 in comparison to insulin aspart and fast insulin aspart. …

[HTML][HTML] Factors affecting the absorption of subcutaneously administered insulin: effect on variability

AKJ Gradel, T Porsgaard, J Lykkesfeldt… - Journal of diabetes …, 2018 - hindawi.com
… shown to accelerate absorption of insulin aspart in healthy … The jet injection results in the
depot being dispersed in a spray-… One study conducted in people with type 1 diabetes showed …

New ex vivo method to objectively assess insulin spatial subcutaneous dispersion through time during pump basal-rate based administration

P Jacquemier, Y Retory, C Virbel-Fleischman… - Scientific Reports, 2023 - nature.com
… in patients with type 1 diabetes treated with insulin pumps. … it is when the insulin depot is the
largest in our tests, and therefore … mg/mL was mixed with insulin Aspart Novorapid U100 and …

Short‐acting Insulin Analogues

K Hughes and, G McKay - Diabetes Drug Notes, 2022 - Wiley Online Library
insulin have been shown. The emergence of fast‐acting insulin analogues (insulin lispro,
insulin aspart and insulin … the structure of human insulin using recombinant DNA technology, …

Therapies for type 1 diabetes: current scenario and future perspectives

V Pathak, NM Pathak, CL O'Neill… - … and Diabetes, 2019 - journals.sagepub.com
… glargine plus insulin glulisine with biphasic insulin aspart (… Randomised trial to evaluate the
therapeutic applicability of … In addition, novel strategies are also being tested to enhance islet …

Treatment of patients with type 1 diabetesInsulin pumps or multiple injections?

J Krzymien, M Rachuta, I Kozlowska… - Biocybernetics and …, 2016 - Elsevier
… in numerous, randomized clinical trials conducted to date [4]. … in patients with type 1 diabetes
improves treatment results in … that guide the initiation and management of insulin therapy to …

Moving toward the ideal insulin for insulin pumps

E Cengiz, B Bode, M Van Name… - Expert review of …, 2016 - Taylor & Francis
… , two 24-week, randomized trials were conducted in patients (… T1D treated by CSII with insulin
aspart or insulin lispro for at least … the absorption and dispersion of other injected drugs by …